BBCA train has hit a tractor and trailer on a level crossing in Herefordshire, bringing rail services to a halt.
The train has not been derailed, but there were 56 passengers on board the Manchester-to-Cardiff train and a number of them are understood to have suffered minor injuries.
British Transport Police said six people were being assessed my medics.
Ambulance crews were called to an incident on the track at Nordan Farm, Leominster, just after 10:45 BST.
The air ambulance has been deployed, alongside land ambulances and paramedics.
Transport for Wales (TfW) said services had been stopped after the 08:30 from Manchester Piccadilly struck the vehicle on a crossing between Ludlow and Leominster.
National Rail said all lines were blocked between Hereford and Craven Arms, and services between those stations would be cancelled or changed, with disruption expected until 19:00.
A TfW spokeswoman urged people to check before travelling and said tickets would be accepted by other operators.
British Transport Police (BTP) said its officers were at the scene, alongside others from West Mercia Police, as well as fire crews.
A BTP spokesperson said inquiries were ongoing to better understand the circumstances leading up to the crash.
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