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Day: 13 December 2024

The Simple Meditation Technique That Changed My Life

“Stay in the moment. The practice of staying present will heal you. Obsessing about how the future will turn out creates anxiety. Replaying broken scenarios from the past causes anger and sadness. Stay here, in this moment.” ~Sylvester McNutt For two years, I studied and practiced meditation. I listened to podcasts, chanted mantras each morning, sat quietly while exploring my default mode network, and traversed Eastern mysticism under the guidance of a licensed clinical psychologist who taught me how to use deep diaphragmatic breathing to stimulate my vagus nerve and lower my resting heart rate. This helped me recover from panic attacks, which I started having as a result of existential dread. After a series of nights with intrusive thoughts about death and dying, and painful memories related to my childhood, I decided to learn how to meditate so my thoughts would bother me less. It’s important to examine our feelings and emotions in order to determine what to do with them. While meditating, as you nonjudgmentally observe your thoughts, the goal is to let the thought pass and then go back to the present moment with a mantra. However, after your meditation session is over, it’s also important to catalog for yourself if a thought or memory keeps surfacing, and what feelings or emotions might be present with that experience, so that you know what to work on in your personal development. For myself, I found that many of the childhood memories that kept surfacing during meditation were related to my mother. Not surprisingly, much of my early writing as a poet includes themes and ideas related to my mother and other family issues. It was only once I started to really tackle these memories that I realized that they were attached to painful emotions directly linked to my childhood. Once I gave myself the space I needed to examine my memories as artifacts from my life—ones to be accepted and not ones that I wanted to give power to—I was able to work through them and come out on the other side. In order to do this, I started journaling, speaking about my experiences more with trusted advisors and through my creative work, and keeping up with meditation practices, which I did judiciously for three to four hours every morning. One childhood memory that used to bother me a lot before I worked through it was from a time when I was about seven or eight years old. I remembered it vividly, as the memory would keep resurfacing each day. A friend of mine and I were sitting on the floor of my bedroom, talking, when my mother came into the room. She commented sternly about how my clothes weren’t put away yet, since she’d told me having my friend over was contingent on that. She then, without saying another word, picked up every article of clothing and proceeded to throw each of them at me while I was on the floor. My friend and I were speechless. Afterwards, when my mother left the room, my friend helped me pick them up. What I realized by nonjudgmentally accepting my memory is that this experience had become a trauma point for me, one that I carried with me into my adult life until I started dealing with the emotions that were hardwired into my brain related to the event. Only once I started meditating and kept seeing this memory resurface again and again—thereby noticing that I even had the memory and emotions in the first place—was I able to deal with the fact that this instance caused me to feel wronged because of how unfair it was. I felt humiliated. I felt ashamed. How could she have done something like this, I wondered? However, once I began naming my feelings one by one, I found that the bodily sensations and experiences of the emotions surrounding the memory began to fade. I even found the courage to speak with my mother about my childhood using nonviolent communication strategies as discussed in the book Nonviolent Communication, written by Marshall B. Rosenberg, PhD with a foreword by Deepak Chopra. The most rudimentary format of nonviolent communication entails communicating about conflict by saying, “When I hear you say X, I feel Y, because I need Z,” which makes the other person more likely to be able to receive your communication without being reactive or defensive. I found great success with this approach, and while my mother and I are not close by any means, this communication approach strengthened our relationship and my relationship with myself. Now, most, if not all, of my painful childhood memories are no longer traumatic for me, including the one about my clothing. This memory and the emotions that used to be attached to it are literally nonissues for me now, years later. And yet, the most important form of communication that I found for myself is the communication with the self, all brought on by a healthy meditation regimen. So, how does one meditate with the goal of nonjudgmentally observing one’s thoughts, letting them go, and returning to the present moment in order to be successful with processing painful childhood memories and to gain more self-awareness overall? The technique that my psychologist taught me is that, at the same time as doing deep diaphragmic breathing to stimulate the vagus nerve and promote inner calmness (eight seconds in, pause, then eight seconds out), it’s good to have an intention in mind that you can chant in your head as inner dialogue. He also suggested audiating for stronger results, or putting the mantra to music in your mind, which I found was even more intellectually stimulating and led to greater mental clarity. The idea is to try to clear your mind of all thoughts except the mantra, which you have going on repeat. I chose the mantra “Hamsa” for each breath, which means “I am that which I will become,” representing personal development. When my thoughts wandered while I

The Next Steps in Parkinson’s Disease Research – The Health Care Blog

By STEVEN ZECOLA Steven Zercola is back with his latest insights into research in Parkinson’s disease. You can say previous part of this series here In its latest report, the National Institute of Health (NIH) references 508 active Parkinson’s disease (PD) projects as the recipients of $243M in grants. A few caveats are warranted about these numbers: The information is not as precise as it seems.  The NIH report states that: “NIH does not expressly budget by category”. Rather, it “categorizes diseases, conditions, and other research based on a computerized process that it uses at the end of each fiscal year”. NIH alludes to $74 million of the overall budget as indirect costs without an explanation of this distinction. Only about half of the aforementioned research grants are available to review. The NIH report specifies that “{t}he minimum reporting threshold for a specific disease/condition is $500,000”. NIH isn’t the only federal government agency providing grants for PD research.  For example, the Department of Defense also maintains a budget for PD research, albeit much smaller. Generally speaking, one can categorize basic research into having exploratory, explanatory or diagnostic objectives.  Given that basic research for PD has gained some important insights over the past several decades, I have added some PD-specific categories to the more general categories of research, as shown in the chart below. Once these additional categories were identified, I assigned each of the reported studies and associated costs to the corresponding categories as follows: Category Number Costs ($000) Explanatory 50 18,162 Exploratory 32 13,178 Diagnostic 21 11,499 Tools 7 4,444 Biomarkers 9 3,541 DBS 13 3,598 Alpha-synuclein 38 16,642 Physical therapies 17 18,119 Indirect 27 18,975 Total 214 $108,158 As you can see from the activity on explanatory and exploratory research, NIH is still very much in a discovery mode when it comes to PD research.  From my perspective as a patient, only about 25% of these identified grants are in a position to produce game-changing results within the 10-year window of the legislation (namely, tools, biomarkers and alpha-synuclein). In terms of clinical research, clinicaltrials.gov provides a listing of all trials, broken down into phases, including those that are completed, recruiting or terminated.  However, the inputs are not reviewed by an independent party, and the overall numbers are not reliable and do not reflect the funding status of the trials. Nevertheless, there are a series of individual trials that show promise. A dozen or so trials target alpha-synuclein either by 1) reducing alpha-synuclein by immunization; 2) blocking misfolding of alpha-synuclein; 3) blocking alpha-synuclein aggregation; or 4) reducing alpha-synuclein synthesis. For example, Prasinezumab is designed to block the transmission of the aggregated forms of alpha-synuclein. The PROPEL Study tests a one-time gene therapy drug for people with Parkinson’s disease and a GBA1 gene mutation. Johns Hopkins is studying the safety and tolerability of RO-7486967, a small molecule designed to inhibit inflammation in Parkinson’s disease. Ambroxol is in a phase 3 clinical trial to test its long-term efficacy in slowing the progression of the disease. The above examples are provided for illustrative purposes only and by no means are near complete. Nevertheless, the two most important areas for PD research right now are 1) finding an easily administered biomarker for the disease and 2) finding a way to stop or reverse the clumping of the alpha-synuclein protein in the brain.   Finding an easily administered biomarker would enhance the pursuit of a cure by providing a quick and definitive cause and effect relationship of certain approaches.  In the case of alpha-synuclein, research has shown a direct correlation between clumping of alpha-synuclein protein in the brain and the death of dopamine producing cells.  Therefore, if the effects of alpha-synuclein can be halted or reversed, the Holy Grail of PD research can be reached. Separately, Terazosin deserves a special mention.  Several scientists found that those people who took Terazosin over an extended period of time had a lower incidence of PD and a slower progression of the disease if it manifested itself.  The drug had been approved by the FDA thirty-five years ago for other uses.  Yet it has taken years and millions of dollars for the drug to go through a Phase 1 trial to determine if it is safe.  This is a good example of unnecessary regulation at its worst. A New Approach Significantly, in July of this year, the President signed into law the National Plan to Cure Parkinson’s Disease.  In essence, the legislation requires HHS and other funding federal agencies to become more efficient and effective with respect to PD research. The HHS Secretary with advice provided by an Advisory Council has been tasked by the legislation with sorting out the strategic direction for PD research. As this program kicks off, there are several steps that can be taken to improve the effectiveness of PD research. First, all federal PD grants should be administered under one agency and coordinated with oversight by one person/office on a dedicated basis. Second, at this point in the research cycle, grants for basic PD research should be more limited in scope and increased in dollar value.  For example, additional tools such as provided by Artificial Intelligence as well as having an easily-administered biomarker for the disease will have disproportionate positive effects.  Therefore, the amount and size of commitments to these projects should be increased provided that the specific project is not being pursued in the private sector. Third, grants for physical therapies such as exercises, music and various forms of brain or body stimulation should be wound down and left to the private sector. The payback period on this research is comparatively short and the potential benefits are more limited compared to the other categories. Fourth, unless the Advisory Council finds a high degree of uncertainty from the ongoing clinical trials, basic research in exploratory and explanatory matters should be scaled back while research for specific diagnostic efforts should continue, where such diagnostic research aims to understand “why” something is happening by